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Weight-regulation genes like FTO rs9939609 and MC4R rs17782313 influence baseline metabolic dysfunction and appetite signaling
ELAD was not powered for those outcomes, so it reads as encouraging but inconclusive
doi: 10.1016/S2468-1253(21)00014-5 14 MarrieRAGraffLAFiskJDPattenSBBernsteinCN
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Table 1 illustrates that the most significant obstacles to progress across these systems have not been a lack of physiological relevance, but unresolved pharmacologic, technological, or conceptual challenges
Improving levels may help emotional stability and wellbeing. 9
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