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Don't use this stack if you're pregnant or nursing, under 18, have active cancer, or have contraindications to GLP-1 medications (medullary thyroid carcinoma history, MEN2 syndrome, pancreatitis history)

doi: 10.1056/NEJMOA1607141/SUPPL_FILE/NEJMOA1607141_DISCLOSURES.PDF 15 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

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The combination is also contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs , due to the risk of hypertensive crisis