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Prepare for more intensive utilization management as indications expand

The CAA 2026's rebate pass-through mandate and spread pricing ban, the FTC's Express Scripts settlement, and Express Scripts' own announcement to transition to a rebate-free model by 2028 all signal a structural shift away from the opaque, rebate-driven model that has defined PBMs for decades

These drugs work by mimicking the incretin hormone GLP-1, which reduces appetite, slows gastric emptying, and improves appetite suppression signaling in the brain

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