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Proc Natl Acad Sci USA 93 : 83188323 Werner H, Le Roith D (2000) New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia

The absence of these peptides makes it less affinity to IGFBPs, thus more effective because it will stay in the host body long enough to exert the desired pharmacological actions

DSIP (Delta Sleep-Inducing Peptide) is an endogenous neuropeptide composed of nine amino acids, with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

Authors acknowledge financial support of the Deanship of academic research at the University of Jordan

To determine whether systemic inflammation was reduced, we further examined C-reactive protein (CRP), a nonspecific marker of systemic inflammation 47,48