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Key trials included SUSTAIN 6, a cardiovascular outcomes trial demonstrating significant reduction in major adverse cardiovascular events (MACE) compared to placebo (HR 0.74

In a 48-week study, participants experienced an average weight loss of approximately 24% of their starting body weightsignificantly higher than whats typically seen with existing medications

These are pathway-level associations only and do not predict how much weight you will lose or how you will respond to any specific medication

For naltrexone-bupropion it cites boxed warnings covering neuropsychiatric effects and seizure risk, singling out patients with prior seizures or psychiatric conditions

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