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Sugimoto, M., Ohno, T., Graham, D

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Introduction: Two Dominant Anabolic Research Pathways Skeletal muscle hypertrophy research is anchored around two primary mechanistic axes: the IGF-1/IGF-1R-PI3K-Akt-mTORC1 signalling cascade driving protein synthesis, and the myostatin-ActRIIB-SMAD2/3 pathway governing muscle mass ceiling (the brake on hypertrophic growth)

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