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When the cold chain fails, the risks span multiple dimensions: Reduced therapeutic effect Temperature instability breaks down active ingredients, leading to decreased potency and inconsistent absorptionultimately reducing the medications effectiveness
doi: 10.1056/NEJMe2202547 123 IottiS.WolfF.MazurA.MaierJ
5.4 Probiotic adhesion to the mucosa and host interaction Probiotics play an important role in regulating the synthesis and structural composition of the protective mucus layer that coats the intestinal epithelium (117)
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