Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors
These can often be managed with simple measures (e.g., analgesic for headache, proper injection technique for site pain)
In a 2024 systematic review and meta-analysis, researchers found that some GLP-1 drugs were more likely to cause diarrhea than others
The practical upshot is that the anti-inflammatory effect seems to operate even at low doses what clinicians increasingly call microdosing, which Ill return to below
A 2020 retrospective analysis of 4,217 patients on concurrent ARB and systemic corticosteroid therapy found that systolic blood pressure rose by a mean of 8.4 mmHg within 14 days of corticosteroid initiation, compared to 1.2 mmHg in matched controls receiving ARBs alone [3]