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Current treatments and research aim to suppress such inflammatory cascades and alleviate symptoms

5-HT signaling system is very important in visceral hypersensitivity, and many scholars believe that 5-HT ergic neurons are the underlying structure for the regulation of visceral sensorimotor and autonomic functions (82).A randomized trial found that serum levels of 5-HT were higher in GERD patients than in healthy subjects

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A systematic review and meta-analysis of nine studies involving 294 animals demonstrated that melatonin significantly improved learning abilities and corrected memory deficits in AD models [217]