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20%30% of patients receiving high-dose cisplatin will develop AKI, whose core diagnostic features are acute elevation of serum creatinine and rapid decline of Glomerular Filtration Rate (GFR), and up to 40%100% experience hypomagnesemia (Manohar and Leung 2018)
We chose the monothiol mutant PfGrx C32S/C88S for our studies to avoid side reactions that complicate the steady-state kinetics 33
Moreover, MRP-1 gene silencing results in cellular GSSG accumulation and cell death 33
MedVi has also developed an innovative and beneficial sublingual tablet version of semaglutide, that can be used once each day, which is dissolvable under the patients tongue
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