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Being honest about that gap is not a weakness of this guide it is the accurate picture, and it is why every dosing figure here is framed as a research protocol rather than a recommendation
The authors attributed the effect mainly to ERR engagement in cardiomyocytes, which normalized fatty acid metabolism and mitochondrial function without reversing hypertrophy itself
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The safety and pharmacology data behind this profile isnt thin six controlled trials covering roughly 900 participants, compiled in Stier et al
"Animal models do not always translate into humans
