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Precisely add 1.0 mL of 0.1% formic acid aqueous solution to the residue, sonicate for 1 min to dissolve the residue, and filter through a 0.22 m membrane for analysis by liquid chromatography-tandem mass spectrometry
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Cold fluid entering warm tissue causes vasoconstriction (blood vessel narrowing) at the injection site, which can slow initial absorption and increase the sensation of pressure
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