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Bracken ferns while toxicity symptoms vary widely based on dose, duration, and species of affected animals contain thiaminases, and thiamine deficiency has been noted in sheep grazing on the plants in Australia

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Omeljaniuk WJ, Laudaski P, Miltyk W

A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation