Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data
doi: 10.13294/j.aps.2018.0018
If I could extrapolate, I could also think that the GIP might increae the risk of CV events
Best noted that doctors could also recommend other GLP-1 drugs such as liraglutide (Victoza, Saxenda) or even explore weight loss drugs that work through different mechanisms like phentermine, bupropion, or naltrexone
7 The Breast Cancer Weight Loss (BWEL) trial tested a structured weight-loss programme in 3,180 women with stage II or III breast cancer