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In osteoarthritis, pain relief is often attributed to weight loss rather than direct analgesic effects, complicating the evaluation of GLP-1RAs efficacy
Participants in RCTs typically comprise relatively healthy individuals, excluding those with a history of medullary thyroid cancer or pancreatitis, and the duration of the RCTs is insufficient to induce cancer
However, the effects of the BASs on GLP-1 secretion are controversial
Wegovy, by contrast, is used for obesity at the higher 2.4 mg dose and achieves mean weight losses of 14 to 16%
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