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Epub 2020 Dec 28
Reviewers also note more long-term clinical trials are needed to confirm the full potential
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For general skin anti-aging, systemic subcutaneous injection at 1 to 2 mg/day combined with topical application achieves the best tissue-level collagen response
Topical application and microneedling enhance delivery research like the 2025 Kuceki study shows that combining GHK-Cu with microneedling (which creates micro-channels in the scalp) dramatically improves delivery to the target cells and produces measurable regrowth
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