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When adverse effects do occur, they are usually mild and transient, often related to the route of administration rather than the vitamin itself

Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase

477 This deficiency disrupts the TCA cycle by depleting substrates needed for OXPHOS, leading to a collapse of energy production

Notably, a widespread negative CBV response was evident in the surrounding area of the stimulation site under awake conditions (blue voxels, Fig