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Other areas impacted include the amygdala and prefrontal cortex , which play a role in fear, anxiety, and decision-making

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Whilst gastrointestinal side effects such as nausea and diarrhoea are well-recognised, some patients report joint pain during treatment

These findings indicate that GDF8 and ActA are key regulators of muscle loss during caloric restriction, and that blocking these negative regulators of muscle mass during the treatment of obesity with GLP-1 RAs could provide profound and wide-ranging benefits