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In contrast, those treated with GLP-1 RAs showed significant reductions in the risks of mortality, MACEs, and MAKEs during a median follow-up period of 2.3 years

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By activating both receptors, oxyntomodulin increases energy expenditure, reduces appetite, promotes weight loss, and improves glucose tolerance, showcasing the therapeutic potential of this dual mechanism [79]

Reduced food intake compounds the problem