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Vlachos F, Tung YS, Konofagou EE (2010) Permeability assessment of the focused ultrasound-induced blood-brain barrier opening using dynamic contrast-enhanced MRI
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Compared to larger peptides, which often struggle with poor bioavailability and proteolytic degradation, tripeptides offer a balance of functional stability and conformational flexibility
Mechanistically, the peptide has been studied as a pro-angiogenic agent that appears to work through the VEGFR2 receptor and the endothelial nitric-oxide synthase (eNOS)nitric-oxide pathway, and as a stimulator of fibroblast outgrowth and migration through the FAKpaxillin signaling pathway
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