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Additional evidence from pediatric cancer survivors indicates that Leydig cell dysfunction is frequently present, characterized by a mild decline in serum testosterone accompanied by a disproportionate increase in LH, which has been interpreted as a compensatory response to impaired Leydig cell activity (27, 45)
Prednisone and other corticosteroids can counteract the appetite-suppressing effects of GLP-1 receptor agonists like Wegovy, making weight management more difficult during short-term or long-term steroid courses
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It remains unclear whether any perceived worsening is directly attributable to tirzepatide, coincidental, or related to other factors such as stress, dietary modification, or concurrent medications
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