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Physiol Rev 86 : 10331048
BPC157 has been studied in healthy adults and found to be well-tolerated with no adverse effects on cardiac, hepatic, renal, thyroid, or glycemic biomarkers
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Specifically, blocking the 1-adrenergic receptors with prazosin or the opioid receptors with nalbuphine interfered with the ability of GLP-1RAs to reduce plasma TNF- levels, indicating the critical importance of these pathways in the anti-inflammatory effects mediated by GLP-1 activation
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