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These phase 3 results confirm and extend the phase 2 findings, establishing retatrutide as potentially the most effective obesity pharmacotherapy ever studied

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In individuals with insulin resistance, as well as those with type 2 diabetes, there is an associated elevation in the circulating levels of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine

NIDDK / NIH

Most patients notice their first symptoms between 24 and 48 hours after injection, though some experience effects within hours