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GLP-1 Reduces appetite, slows gastric emptying GIP Enhances insulin, improves fat metabolism Glucagon Increases energy expenditure, burns fat Based on Phase 2 clinical trial data (published in NEJM, 2023), retatrutide's side effects are primarily gastrointestinal, similar to other GLP-1 agonists but with some differences due to the glucagon component
None of the deaths were considered to be related to study medication
A free interaction checker is available from Drugs.com (see Drugs.com interactions checker)
Both very low and very high levels are linked to higher cardiovascular and mortality risk, so the goal is a healthy middle, not the highest number
Used together they are studied for a larger, cleaner GH release than either compound produces on its own
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