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What studies show: People can lose ~15% of their body weight on average with semaglutide The catch: Once the drug is stopped, weight regain is common most people regain much of their lost weight within a year
Beyond these concerns, theres now a family ranging from single to triple G-agonists and we have no idea how such potent interventions should be optimally used
This is the primary safety metric for the insulin resistance concern
It's important to understand that changes in these biomarkers are surrogate endpoints and have not been validated as a basis for selecting specific GLP-1 receptor agonists for anti-inflammatory purposes
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
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