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Muscle preservation requires active attention Rapid weight loss can result in significant lean mass loss
Geographic exclusion is measurable at a finer grain, too
Same incretin pathway Little added efficacy More cost More polypharmacy Rule in practice: stop DPP-4 inhibitor before starting semaglutide unless there is a very unusual reason not to
There is no clinical data to answer this question
RELATED STORY | Hims and Hers likely to stop selling cheaper versions of GLP-1 medications The drugs have been in short supply since 2022, soon after the FDA approved Wegovy for weight loss purposes
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