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While a single 5-mg dose pharmacokinetic study cannot provide long-term data, results from phase III studies consistently showed decreases in mean alanine transaminase and aspartate transaminase values in people with T2D treated with tirzepatide (mean percent changes from baseline ranged from 12 to 33% for alanine transaminase and 1 to 16% for aspartate transaminase) [9,10,11,12,13]
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Published online June 5, 2026
Because these tests dont always show the full picture, its best to measure at least two parameters before diagnosing a B12 deficiency
In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis
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