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These two characteristics make it inherently unsuitable for standard topical delivery: it degrades before it absorbs, and it repels the lipid-rich skin barrier

Patients experiencing hives, facial or throat swelling, wheezing, or difficulty breathing should discontinue use and seek emergency medical care

doi: 10.1155/2012/674142

Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers