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Signs of gastrointestinal obstruction : Severe bloating, inability to pass gas or stool, or progressive abdominal distension may indicate bowel obstruction, a rare but serious condition requiring urgent evaluation

There is a risk of muscle loss if not paired with strength training

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however, clinically viable GLP-1 receptor agonists did not emerge until advances in peptide stabilization, delivery, and dosing strategies were achieved ( The delayed translation of GLP-1 illustrates a critical principle: biological validity alone is insufficient for therapeutic success