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The changes resulted in a decrease in serum GLP-1 along with insulin resistance and metabolic dysfunction
Taken together with the observation of elevated lipase concentrations in patients treated with GLP-1 receptor agonists [9], it is conceivable that these drugs exert some effects on the exocrine pancreas, although a specific mechanism of action has not yet been identified, and the presence of GLP-1 receptors in pancreatic exocrine cells is still a matter of dispute [10]
In addition to cochlear effects, quinine has been associated with vestibular toxicity, resulting in balance disturbances and dizziness (Semedo et al
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