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Data presented herein support the notion that prolonged exposure to GLP-1R stimulation can also induce glucose competence by a secondary mechanism involving up-regulation of glycolytic enzymes, and consequently glycolytic flux, arguably the most important stimulus-secretion coupling factor generating pathway in -cells
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(5) C Laustrup Mller, K Raun, M Lambert Jacobsen, et al (2011) Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved Molecular and Cellular Endocrinology, 2011 Jul 20, Volume 341 (Issues 1-2), Pages 9-17
The gradual onset allows the body to adapt to the medication whilst minimising adverse effects, particularly gastrointestinal symptoms that can occur with rapid dose escalation
They, therefore, have favourable effect on glucose metabolism and lead to significant caloric intake reduction and resultant weight reduction, usually in the vicinity of 3 - 8 kg depending on the dose and agent used
