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Glutathione IV remains in the bloodstream for 2 to 4 hours , depending on metabolism and hydration
It serves as the rate-limiting enzyme for the de novo synthesis of GSH, which is promoted by glutamate cysteine ligase (GCL) and glutathione synthetase (GSS)
This signaling pathway facilitates the upregulation of integrin 41 on LECs, consequently attracting VCAM-1-expressing tumor cells (195) ( Figure 4D )
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Oussoren, C., Zuidema, J., Crommelin, D
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