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Permeability barriers and detoxification [edit] That the exact compounds an organism is exposed to will be largely unpredictable, and may differ widely over time, is a major characteristic of xenobiotic toxic stress

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[14] Final solvent concentration should therefore be reported, matched across control and exposure groups, and validated for the specific model system rather than assumed to be biologically inert

Published studies have identified peptide sequences that influence antimicrobial defence peptide expression, lipid synthesis in the stratum corneum, and the signalling cascades that drive keratinocyte differentiation