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Andersen JM, Ronning PO, Herning H, Bekken SD, Haugen TB, Witczak O
Nutrient-regulated phosphorylation of ATG13 inhibits starvation-induced autophagy
The liver processes these substances through two main phases
These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity
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