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What Did the 2025 Meta-Analysis Find About B12 Delivery Methods
The preservation of nicotinamide substrate drastically increases the efficiency of the NAD+ salvage pathway
Face serums and creams: Clinical standard: 1-3% concentration Maximum typically used: 4% concentration Application: Once or twice daily Duration: Minimum 8-12 weeks for visible results Eye area products: Concentration: 1-2% (lower for sensitive periorbital skin) Application: Once daily, typically evening Amount: Pea-sized for both eyes Scalp solutions for hair: Concentration: 0.5% solution common Application: 1-2ml to affected areas once or twice daily Duration: 3-6 months minimum for meaningful changes Higher concentrations do not always mean better results with topicals
Freeze/thaw cycles can degrade peptide structure and should generally be avoided
This approach treats GHK-CU as a maintenance supplement rather than an intensive intervention
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