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A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]

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To delete the GLP-1R in VSMCs, we used mice expressing an inducible Myh11 -Cre recombinase to generate VSMC-specific Glp1r -KO mice ( Glp1r VSM/ mice) (21)