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Moreover, owing to its ability to increase nerve growth factor production (Yamaguchi et al., 1996) and protect against oxidative damage and encephalitis ( PQQ can stimulate new mitochondrial growth in cells by increasing peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1) and activating the transcriptional networks ( PQQ was launched as a food ingredient in the United States in 2008

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This emerged from the work of Janet Mertz, Paul Berg, and Stanley Cohen at Stanford University and Herbert Boyer at the University of California San Francisco