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A meta-analysis of 12 RCTs (N=2,994) found that systemic corticosteroid use increased the odds of developing hyperglycemia by 2.3-fold (95% CI 1.7-3.2) compared to placebo, with the effect most pronounced in afternoon and evening glucose readings [13]
These studies establish SGLT-2i as a cornerstone therapy for HF across the disease spectrum (54, 61)
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