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GLP-1 medications carry risks including pancreatitis, gallbladder disease, and potential thyroid C-cell tumours based on animal studies
NICE Technology Appraisal 875 (Wegovy) and TA664 (Saxenda) recommend these treatments within specialist tier 3 or 4 weight management services for adults with a BMI of 35 kg/m or above (or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds), with weight-related comorbidities
(Online) 2349-0365 DOI: Yang Y, Bu D, Zhao X, Sun P, Wang J, Zhou L
Who should consider GLP-1 supplements Not everyone needs a GLP-1 supplement
Its unclear how such a treatment would react with adenosines immunostimulatory, primarily anti-inflammatory, effects in distinct immune cell types, 152 or how elevated DPP4 activity and prolonged subclinical inflammation in obesity-induced MS would impact the therapeutic outcome
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