doi: 10.1038/s42255-025-01342-6 Knerr PJ, Mowery SA, Douros JD, Premdjee B, Hjllund KR, He Y, Kruse Hansen AM, Olsen AK, Perez-Tilve D, DiMarchi RD, Finan B
Pivalate is a branched-chain fatty acid anion that is metabolized to form an acyl-CoA ester, which is transesterified to carnitine and subsequently excreted in the urine as pivaloyl carnitine
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Previous studies found that butyrate and acetate enhanced mucus production, increase its thickness, and upregulate MUC-2 expression through the release of prostaglandin E1
That was my first hint at just how fragile this whole system is how much depends on crowdsourced trust and trial-and-error