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NEJM 2023, PMID 37356779, ran 338 adults with obesity (mean BMI 37.3) but without type-2 diabetes for 48 weeks against placebo
A selective CPT-1 stimulator produced long lasting hypophagia (reduced food intake) and persistent weight loss [75]
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If proven equally effective, they could dramatically expand adoption, especially among patients needle-averse or unwilling to self-inject
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