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This pre-specified analysis of pooled data from the two trials investigated whether the effects of semaglutide vs
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Furthermore FFAR2 activation in vivo with an inulin-enriched diet in mice results in PYY release and proliferation of L cells in vitro ( in vivo involvement of FFAR2 and FFAR3 in GLP-1 modulation (301, 302), with some reports indicating that blockade of GPR43 in vitro releases GLP-1 (303) and others indicating different mechanisms of action, with FFAR2 releasing PYY from intestinal L-cells (295) despite its apparent expression by the majority of enteroendocrine cells ( In pancreatic -cells, both GPR43 and GPR41 are expressed, and the latter antagonizes GSIS (304)
Lichtenstein E, et al
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