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There is also evidence for mechanisms involving a reduction of neuroinflammation, an increase in synaptic functioning, as well as the restoration of brain pathways of insulin signaling that may lead to improved memory formation and therefore a positive effect in Alzheimers disease and Parkinsons disease, note the authors

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Notwithstanding, in pharmacokinetic studies, patients with moderate or severe hepatic impairment showed no increase of drug exposure after administration of multiple doses of linagliptin, compared to normal controls

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