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Whether the heptapeptide fragment fully recapitulates the parent proteins effects in vivo is unresolved
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10.1161/CIRCIMAGING.109.899377 7
The gut microbiota converts L-carnitine into trimethylamine (TMA), which may then be oxidized by enzymes in the liver to form trimethylamine N-oxide (TMAO)
Importantly, FOXO4-DRI showed no significant toxicity towards normal TM3 Leydig cells, demonstrating its selective action against senescent cells
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