Micu et al., 2016, 2018), oxidative stress (Cheignon et al., 2018), mitochondrial impairment (de la Cueva et al., 2022) (well documented in the MS brain
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The most common switches are: POM to P : Occurs when the medicine no longer meets the legal criteria requiring prescription control (e.g., the risk of misuse or danger to human health without medical supervision is minimal)