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There are no head-to-head studies showing that adding methylcobalamin to semaglutide improves weight loss outcomes, reduces side effects, or meaningfully prevents B12 depletion better than taking a separate B12 supplement

However, it's crucial to understand that semaglutide is not a standalone solution

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Conclusion and Future Perspectives Weight loss, while beneficial for reducing cardiometabolic risk, is consistently associated with adverse effects on skeletal health

This is good news for those on Wegovy, as a recent study found that Semaglutide appears to improve cardiac remodelling