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Giugliano D, Scappaticcio L, Longo M, Caruso P, Maiorino MI, Bellastella G, et al
Besides, cell penetrating peptides seem promising to increase skin permeation of GHK and its derivatives
[19] However, the pharmacodynamic effectsparticularly on gastric emptying and appetitemay be different in patients with reduced gastric capacity, potentially requiring more cautious dose titration than in bariatric-naive patients
In particular, the SURMOUNT-1 trial demonstrated that patients on tirzepatide experienced up to 22.5% weight loss , while semaglutide users typically averaged around 15% at the highest dose
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