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In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]
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As with most treatments, there are some mild side effects
low-dose tricyclic antidepressants (e.g., amitriptyline 10mg at night, with gradual titration) for pain and altered motility For IBS-C : Laxatives such as macrogols (polyethylene glycol)
In animal models finerenone reduced the expression of genes encoding monocyte chemoattractant protein-1, matrix metalloproteinase-2 and plasminogen activator inhibitor-1 (related to tissue remodelling and fibrosis) in the kidney, and additionally demonstrated beneficial immunomodulatory effects [73]
