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Generally, depression is becoming more common among adults in recent years

Discontinuation rates due to side effects reached approximately 10% across all dose levels

Because long-term disability often reflects network disconnection, metabolism-focused studies should assess myelin integrity, axonal conduction, diffusion-tensor imaging, and preservation of the corpus callosum and corticospinal tracts

Diagnosing POTS requires a thorough clinical evaluation, including a detailed medical history, physical examination, and specialized tests

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