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In a post hoc analysis from the PROactive trial, weight gain with pioglitazone, a TZD, which leads to weight gain with a redistribution from VAT to SCAT and improvements in insulin sensitivity 62,63 , was associated with improved CV outcomes (excluding heart failure) 64

UK waist circumference thresholds associated with increased health risk are 94 cm for men and 80 cm for women

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Proper site rotation helps prevent skin irritation and makes future injections more comfortable